Previously disparate disciplines are now converging with the aim of untangling the complex basis of human disease, and all disorders are now considered 'genomic', contributed to by myriad variants differing in frequency, size, location and effect.
Service activities are basis of human living and should be treated as complex systems including mutual interactions of various players.
Examples include projects to determine the molecular basis of complex human diseases such as cancer [ 1], to study the incredible diversity and function of the human microbiome [ 2], to rapidly identify the origins of pathogen outbreaks [ 3], and to generally develop a deeper understanding of the living world through the increasing use of large-scale sequencing.
His team uses experimental and computational analysis of genetic information to understand the basis of complex human diseases, both rare and common, such as Hirschsprung's disease, autism, hypertension, and sudden cardiac death.
These results provide important new insights concerning the cerebral basis of complex human cognition such as planning and multitasking.
Using mice in GWA studies can help to accelerate the identification of the genetic basis of complex human diseases.
Within such models, epigenomic profiling could be especially helpful in understanding the genetic basis of complex human disorders, where most of the causative variants are predicted to occur within the vast non-coding fraction of the human genome.
Novel, albeit limited, insights into the molecular basis of human disease have resulted from the use of high-resolution, microarray-based platforms to comprehensively study complex diseases at multiple levels of the genetic program.
