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Despite recent advances in our understanding of the complex interplay between Salmonella and their hosts, the molecular basis of host range restriction and unique pathobiology of Gallinarum remain largely unknown.
Further investigation of the molecular basis of host range restriction is therefore important.
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Although the molecular basis of host-range restrictions is not completely defined, the compatibility between the HA protein of the virus and its corresponding receptor, sialic acid, on the host cell is thought to contribute in part to the infection of the virus in a specific host [31], [32].
However, our knowledge of host range across the B. tabaci complex is decidedly patchy with much of our knowledge being assumed on the basis of scant comparisons against the highly invasive MED and MEAM1 both of which have a very broad host range.
The poxvirus C7L family of host range genes functions by mediating poxvirus host range and antagonising the host defence system [ 60].
The molecular basis for host range restriction is not well understood; however, HA plays a key role in the restriction of interspecies transmission.
The P. syringae species is thus subdivided into more than 50 pathovars, which are mostly described on the basis of plant host range [4].
Similar observations were reported for comparison of P. syringae pathovars T3E repertoires [ 56], thus reinforcing the idea that a complex genetic basis underlies host range evolution in plant pathogens.
Blanco-Urgoiti et al. [ 4] identified two different 'genetic strains' of PVYC (PVYC1 and PVYC2), which were separated on the basis of genetic distances, host range, reactions to the monoclonal antibody 10E3 and the coat protein processing site.
We have recently been able to tie down the genetic basis of this host-range expansion in the phages.
We also established the multigenic basis for host-range transmission, but many unanswered questions persist.
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