By contrast, on the basis of high-confidence activity data, the final (>2012) promiscuity rate of imatinib was 24.
On the basis of high-confidence activity data, an increase in the average drug promiscuity rates from only 1.5 to 3.2 targets per drug was observed.
On the basis of high-confidence activity data, an increase in average promiscuity rates from 1.5 to 3.2 targets per drug was detected between 2000 and 2014.
However, the magnitude of such increases as a consequence of data incompleteness is difficult to predict, especially considering the low promiscuity rates that can currently be confirmed on the basis of high-confidence data.
For the 518 drugs, increases are reported in Table 2. Surprisingly, for 282 drugs (~54%), no increase in promiscuity was detected on the basis of high-confidence activity records.
In a previous study (reference 11), it was shown that representative promiscuous compounds identified on the basis of high-confidence activity data are rarely weakly potent against their targets (which we consider an interesting observation).
On the basis of high-confidence activity data, it has also been calculated that compounds from ChEMBL interact on average with one to two targets and compounds from PubChem confirmatory assays with two to three targets.
Furthermore, when considering the results obtained on the basis of high-confidence activity data, the findings also corroborated conclusions drawn from earlier studies discussed above, which indicated that detectable promiscuity of active compounds and drugs might be lower overall than often assumed (and that these observations might not be largely determined by data incompleteness).
Hypercorrection of high confidence errors in children.
These 1,045 genes represent a collection of high confidence intestine expressed genes, supported by at least three independent approaches, and will provide important insights in unraveling the genetic basis of intestine tissue identity in worms.
In addition, please, see the conclusions, especially the second part beginning with " On the basis of high- confidence activity data... .......... 500+ drugs successfully mapped to ChEMBL to follow a time course of promiscuity.
