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The conserved TFBS are detected solely on the basis of genome sequence and are therefore independent of experimental conditions and cell type [ 33].
The Arabidopsis heat shock proteins (Hsps) and transcription factors (Hsfs) have been well characterized on the basis of genome sequence information [ 1, 11- 14].
This coverage has been recently extended to anthozoan cnidarians on the basis of genome sequence from a sea anemone [ 42] and EST sequences from three corals [ 32, 36, 37].
Interestingly, during the preparation of this manuscript Marenholz etal., [ 9] have argued that the possible ancestral homolog of the human S100A7 paralogs [ 10] has been identified in the mouse on the basis of genome sequence analysis and gene orientation, but has not been characterized fully as yet.
However, based on our more detailed comparative analysis of entire proteomes of human and chimpanzee there are genuine significant differences between proteins of human and chimpanzee that can not be easily explained on the basis of genome sequence quality and gene prediction.
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This technique was first described by Sanger et al. [ 7] and has been refined and used as the basis of genome sequencing and assembly ever since.
Although the functions of the genes encoding transcriptional regulators or sigma factors of RNA polymerase may be assigned using comparative genomics, their role and connections in cell regulatory networks could hardly be deduced on the basis of genome sequences alone.
The nine strains were selected on the basis of genome sequencing projects (Doniger et al. 2008; Liti et al. 2009) and their phenotypic diversity within a larger collection of yeast strains.
On the basis of genome sequences for a total of 63 evolved populations, our aim was to address the following three questions: 1) Which trait functions, genes, and/or molecular mechanisms show patterns of convergent evolution in the resistant populations and are thus potentially adaptive (cf. Christin et al. 2010; Wake et al. 2011)?
Discoveries could be used to personalize medicine so that treatments can be tailored for individual patients on the basis of the genome sequence of the infecting microbe.
On the basis of whole genome sequence information, we can continuously detect and update causal gene lead to defects of the cultivar improved by the Update breeding.
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basis of genome instability
basis of genome size
basis of genome stability
basis of genome sequencing
basis of available sequence
basis of genome alignment
basis of genome arrangement
basis of genome analysis
basis of genome diversity
basis of genome organization
basis of genome shock
basis of limited sequence
basis of genome annotation
basis of multiple sequence
basis of nucleotide sequence
basis of genomic sequence
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