The goal of this study was to classify SERMs on the basis of gene expression profiles of breast cancer cells expressing either wtERα (D351) or mutant351ERα (D351Y) after exposure to SERMs for 24 h.
The main objectives of microarray studies are (1) to identify homogeneous subtypes of a disease on the basis of gene expression, or (2) to find genes that are differentially expressed in tumours with different characteristics or (3) to develop a rule on the basis of gene expression allowing the prediction of patient prognosis or of the response to a particular treatment.
When added as a medium supplement to 2D cultures of MSCs, urea-extracted fractions of the inner (imECM) and outer meniscal ECM (omECM) enhanced cell proliferation while imECM most strongly upregulated fibrochondrogenic differentiation on the basis of gene expression profiles.
A similar mechanism is postulated for various other substances on the basis of gene expression analyses, e.g. for nonylphenol, di- 2-ethylhexyl phthalate andi- 2-ethylhexyl phthalatef the Comparative Toxicogenomics di- 2-ethylhexyl phthalate.mdibl.org/).
As shown in Figure 2 we observed diagnosis-specific clustering of keratinocyte cell lines on the basis of gene expression data.
Kreike et al. [53] showed that the basal subtype may be further divided into five subgroups on the basis of gene expression profiles.
We identified 565 significant proteins on the basis of iTRAQ data and 668 significant proteins on the basis of gene expression dataset (with FDR<5%, Table S5).
Nucleotide sequence composition is the basis of gene expression and gene function, and the SNP and insertion-deletion sites of genes related to amylopectin structure among different rice varieties have been reported.
Here, we report improved methods for in vitro maturation of cumulus-free human oocytes by supplemented culture media with ovarian paracrine/autocrine growth factors that were selected on the basis of gene expression profiles of single human oocytes and associated cumulus cells.
The term prediction is used here to refer to the ability to predict the triglyceride levels as they were measured on the basis of gene expression, rather than in the sense of prognostic for the future progress of steatosis in time.
We compared the "level of activity" of pathways on the basis of gene expression measurements derived from whole-blood samples in patients with ventricular dysfunction (VD+, ejection fraction ≤40%) and in patients without ventricular dysfunction (VD−, ejection fraction >40%) after MI.
