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These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional data.
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The outlined procedure of approximating data using orthogonal basis functions (here polynomials) and clustering estimated coefficients appears quite naturally in the context of functional data analysis [ 9- 14] 14].
In addition, transferable loci provide a compelling basis to conclude that the sites are real and of universal biological and clinical significance, even in the absence of functional data.
The resulting annotations are then used as a basis for functional data mining including metabolic reconstruction.
p.Met34Thr was then re-classified as a polymorphism on the basis of contrasting functional data and lack of segregation with a hearing phenotype in some families (28).
On the basis of the functional data gained from this MO-based screen in the zebrafish, we are increasing screening throughput by combining Targeted Induced Local Lesions IN Genomes (TILLING) with automated image capture coupled with computer-based pattern recognition of the processes, leading to thrombus formation.
On the basis of functional and structural data, the PTS1-receptor Pex5p comprises two separate parts.
On the basis of these structural and functional data, we proposed a catalytic mechanism involving two proton wires.
Recent efforts demonstrate the importance of sequence information as the basis of functional-genomics studies.
We assume that structural anatomy and functional anatomy correspond to each other, which is also the basis of group analysis of functional MRI data in the FreeSurfer model.
To make sense of this vast amount of data in a timely manner, high-throughput techniques are required to filter and prioritize candidate variants on the basis of the wide range of functional genomic data that are currently available.
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