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These findings show that human breast cancer tumor-induced repression of IL-2 RNA translation is the basis of failure of TIL to express the IL-2 receptor and subsequent T cell hyporesponsiveness.
The reported trial may underestimate the treatment effects of prednisone, given that a primary reason for non-participation was a desire not to discontinue prednisone on the basis of failure of (often many) previous attempts.
Strains were identified as M. africanum West African-1 on the basis of failure of amplification of the RD9 locus but the successful amplification of the RD7 target region, while M. africanum West African-2 strains were putatively identified on the basis of failure of amplification of the RD9 and RD7 loci but the successful amplification of regions within the RD1bcg/RD1das, RD4, and RD12 loci.
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Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder.
DMD is diagnosed at 3 5 years of age on the basis of failure to achieve movement-based milestones.
Multiple EMS-induced mutants, isolated on the basis of failure to complement the lethality of the P insertion chromosome, all had the blue phenotype in germ line clones (Douglas Ruden, personal communication).
The recent rapid growth in demand for highly reliable digital circuits has focused attention on tools and techniques we might use to accurately estimate the reliability of a proposed circuit on the basis of failure rate of the utilized technology.
The likelihood of occurrence of a failure is evaluated on the basis of failure rates (in year) estimated from historical data or expert knowledge.
This forms the basis of the sauce.
Treatment with infliximab was considered on an off-label basis after failure of alternative immunosuppression.
Although the studies are yet to be done, it is hoped that appropriate patient selection for such efficacy trials will be randomised and controlled, and that patients will be selected on the basis of proven failure of UES relaxation.
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