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Although we know a lot about chemotherapy resistance, sometimes it is difficult to explain response of cancer cells to cytostatic drugs on the basis of expression profile of genes involved in drug resistance.
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In this study the TFactor enrichment analysis was performed on two sets of EC-restricted genes categorized on the basis of expression profiles; the sets of genes are highly expressed in i); all EC types (pan EC), ii); only in HMVEC.
These findings demonstrated that in addition to the presence of an insertion element, two isolates could be differentiated on the basis of expression profiles.
On the basis of expression profiles, genes were grouped by using self-organizing maps (SOM) and distance matrix Euclidian on rows (developmental expression) and both rows and columns (stress expression) with 100 maximum iterations.
Hence, on the basis of expression profiles AtDCL3 and OsDCL3b share similar expression domains, although the encoded proteins possess highly divergent dsRBb domains and could therefore be interacting with different RNA substrates.
Unlike the study conducted by Stephens and coworkers [ 15], we did not observe enrichment of nonsynonymous changes relative to synonymous changes in our set of 21 genes chosen on the basis of expression profiles.
A self-organizing map was then used to group melanoma samples into two major clusters on the basis of the expression profile of 44 non-redundant genes that contributed most significantly (cut off set as 10-3.3 10-3.3e change in toe stheus of all modules identified here.
Therefore, the differential expression of some miRNAs in primary malignant melanoma and metastasized melanoma cells in comparison to benign melanocytes opens new horizons in the understanding of the pathogenesis and prognosis of malignant melanoma on basis of miRNA expression profile (Lujambio et al. 2008; Satzger et al. 2009).
Five candidate proteins were selected for functional analysis on the basis of their expression profile, GO category, relevance and novelty.
Can either bipolar disorder or schizophrenia be distinguished from control purely on the basis of gene expression profile?
For clustering samples on the basis of their expression profile, we applied hierarchical clustering based on correlation distance and complete linkage.
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