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Molecular basis of defect in the other patients has not yet been defined.
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However, whether KCBP localizes to cortical MTs in trichome cells is still an open question, cellular basis of defects in kcbp trichomes needs to be examined, direct evidence linking KCBP and F-actin is currently missing, and the role of the mysterious MyTH4-FERM domain remains to be unraveled.
More-modern psychodynamic theories have moved away from the idea of explaining and treating neurosis on the basis of a defect in a single psychological system and have instead adopted a more complex notion of multiple causes, including emotional, psychosexual, social, cultural, and existential ones.
The embryological basis of this defect is shown in Fig. 10.
To determine the cell biological basis of this defect, we investigated the epithelia that will produce denticles.
However, the molecular basis of this defect is unknown.
Knowing the molecular basis of a defect, the direct detection of carriers is possible at the genetic level, thus preventing unintended breeding of the animal [ 2].
The subtle differences that have been uncovered between Sar1A and Sar1B in these studies might also provide an explanation for the molecular basis of the defect in CMRD.
The above data suggest that abnormal cytokine secretion is not the basis of the defect in the T-dependent antibody response.
Although we cannot precisely map the basis of the defect in VAND in the present cross, future backcross studies could be used to identify factors required for efficient transmission in the cat.
The familial and molecular basis of the defect in both species is poorly understood although a previous description of the pattern of inheritance in a canine model in the Newfoundland dog breed suggested either an autosomal dominant with incomplete penetrance or a polygenic mode of inheritance (Pyle and Patterson 1976).
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