On the basis of our current findings, a more detailed investigation of the functional role of loop β6 by site-directed mutagenesis of F296 and flanking residues in the loop region could prove insightful.
On the basis of the current findings and in light of previously published work, we believe further investigational pursuit to evaluate the efficacy and safety of ONS for medically intractable CM is justified.
If the ERN originated in the dorsal ACC, one would speculate that the ERN would not correlate with post-error behavioral or neural measures, on the basis of the current findings.
On the basis of our current findings, we can extend this conclusion to postmenopausal HRT use.
On the basis of our current findings, it is reasonable to speculate that PDE3 and PDE4 are responsible for regulating cAMP levels and therefore PKA activity at a sarcolemmal compartment where PKD activation occurs.
Thus, on the basis of current and previous findings [ 17, 22], there is no evidence of increasing prevalence of antimicrobial resistant pneumococci in PNG.
Further work to understand the neurobiologic basis for the current findings has the potential to identify new targets and pathways, for interventions to decrease the growing burden of progressive parkinsonism in older adults.
Although recent genetic findings certainly challenge the aetiological basis of current diagnostic groupings, it would be premature to suggest a radical overhaul of diagnostic practices until more evidence accumulates.
This illustrates the importance of precision in diagnostic definitions for molecular genetic studies: for instance, on the basis of current evidence, it would seem inappropriate to focus gene-finding studies on adolescents with high levels of symptoms.
While on the basis of current evidence the consensus seems to be that neural mechanisms are the main cause of migraine and that vascular findings only constitute epiphenomena, 27 reports linking migraine with cardiovascular disease have accumulated.
