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The mouse has emerged as a uniquely valuable species for studying the molecular and genetic basis of complex behaviors and modeling neuropsychiatric disease states.
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It is also worth remembering that there are many challenges involved in seeking the genetic basis of complex behavior; behavior is not just affected by genes but is also highly dependent on the environment, for example, including both the immediate and the prior developmental environment (Hoekstra 2010).
A major challenge to understanding the genetic basis of complex behavioral evolution is the quantification of complex behaviors themselves.
► Comprehensive observation allows quantitative description of complex behaviors.
An ideal system for the exploration of elaborate behavioral patterns will include a documented genetic basis for complex behaviors that are well understood and well characterized (Hine et al. 2004).
The fruit fly, known to researchers as Drosophila melanogaster, is oddly enough a perfect model for scientists to study the genetic basis of seemingly complex behaviors.
Dr. Insel's research has examined the neural basis of complex social behaviors, including maternal care and attachment.
Some of the earliest discoveries that revealed a genetic basis for complex behavior were made by analyzing geotaxis the movement of an organism in response to gravity [30], [31].
It's indeed a rare skill indicative of complex behavior.
Examples of ongoing research include organizational principles of metabolic networks, quantitative modeling of cell-biological processes, mapping the genetic basis of complex bacterial behavior, comparative genomics analysis of regulatory networks, the genetic basis of quantitative phenotypic variation, and genomic plasticity and mechanisms of phenotypic adaptation.
Thus, the mouse song should remain an important model in which to study the biological basis of complex communicative behavior, including spoken human language.
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