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Key biological premises that motivate the analysis of gene co-expression networks on the basis of centrality measures are: a. Highly co-expressed genes are more likely to be co-regulated, and b.
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We classified the proteins on the basis of 6 normalized values of centrality.
On the basis of this interpretation, the centrality of node i is expressed as.
This added 4 measures of journal impact to our data set bringing the total number of retrieved, existing measures to 8. In [22] and [15] we describe methods to rank journals on the basis of various social network measures of centrality [13], e.g. betweenness centrality that is calculated from journal citation- and usage graphs.
In today's world the financier's role has grown enormously, and this is the basis of financial wealth and its centrality to our economy.
The Page rank centrality reveals the importance of a node on the basis of its links to other central nodes [33, 34].
Although we estimated the combinations of non-redundant centralities on the basis of the complete protein rankings, these indices were still efficient in defining the group of 22 proteins (Table 2).
The "community centrality" introduced in [15], just as any centrality measure, is a valid basis of forming a ModuLand community landscape, therefore making it possible to include this modularity-based method into the ModuLand method family.
The fourth measure of centrality is eigenvector centrality [28].
Specifically, Freeman [34] reviewed the concepts of point and graph centrality and explained three measures of centrality, namely degree centrality, closeness centrality, and betweenness centrality, in great detail.
This paper employs the graph index, average path length, clustering coefficient and three indicators of centrality, namely weighted degree centrality (WDC), weighted closeness centrality (WCC) and weighted betweenness centrality (WBC).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com