Ten amino acids that have high affinity to three different regions of t-PA are identified by the amino acids location method on the basis of candidate pocket structure of t-PA.
However, to answer this important question, the MPE-model is an appropriate, clinically relevant prototype to determine if cells that are segregated on the basis of candidate CSC markers are predictive of a distinct tumorigenic or invasive phenotype.
For example, we can now propose to test whether MPE-tumors that are segregated on the basis of candidate CSC-markers will display differences in in vitro surrogate measures of the CSC-phenotype (soft-agar colony formation, drug resistance, and/or matrigel invasion) from isogenic tumor cells that don't express candidate CSC markers.
On basis of candidate selection signatures identified by combining strategy, the genes close to the putative outliers were explored using the available annotation of the chicken genome (Annotation Release 102).
On the basis of candidate mRNA sequences, 11 pairs of primers were designed to amplify about 1 kb genomic fragments from the 20 genotypes for each of the 11 genes (Table 2).
Interestingly, top associations from a GWAS of bipolar disorder were enriched in meQTLs [ 38], suggesting that this could be a powerful approach to better understand the molecular basis of candidate SNPs from GWASs.
An early (4 h) and intermediate (12 h) time point was selected for the microarray study on the basis of candidate quantitative real-time polymerase chain reaction (qRT-PCR) analyses of CDKN1A, a gene commonly induced by HDACi.
For Americans who wish to cast their vote on the basis of the candidates' enthusiasm for crosswords, it's a no-brainer.
Ofcom originally advertised for four Channel 4 non-executive positions but is allowed to appoint more, and on the basis of the candidates who applied put five through to the government for approval.
