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Alterations to the genome are the basis of cancer development, but not all mutations cause cancer.
Significant progress has been made using RNAi technology in the investigation of the molecular basis of cancer development.
Although the number of samples examined here is low and thus the wider biological conclusions only preliminary, we believe the experimental and analytical methods developed and combined here offer a first glimpse at the power of pairing genomic and transcriptomic sequencing to understand the genetic basis of cancer development.
Here, genetic variation can also become relevant at the somatic level, for example, in the generation of antigenic diversity or at the basis of cancer development.
Retinoblastoma, the most common childhood intraocular tumor has complex genetic basis of cancer development, initiated by biallelic inactivation of RB1 gene [ 28].
Despite extensive study, the majority of the genetic component of cancer susceptibility has not yet been linked to individual genes, highlighting significant deficiencies in our understanding of the molecular basis of cancer development.
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The detailed molecular basis and stage of cancer development at which this instability arises is actively being pursued.
Identification of regions with copy number aberrations and the genes involved thus offers a basis for better understanding of cancer development [ 6].
Inflammation is a hallmark of cancer development.
Farber, E. The multistep nature of cancer development.
Understanding the genetic basis for cancer development is an important step in the development of novel therapies targeting the CSC.
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