The inhibition of activity of enzymes, which participate in the synthesis of peptidoglycan, is the basis of activity of many antibacterial antibiotics such as β-lactams (e.g., penicillins and cephalosporins), glycopeptides (e.g., vancomycin and teicoplanin), fosfomycin, daptomycin, nisin, bacitracin, and many others.
In this paper, we simplify the activity modeling process by relying on the relevance weights of objects as the basis of activity discrimination rather than on sequence information.
It was developed on the basis of activity in rodent models of parasitic worm infection rather than inhibition of a precise cellular target and its mode of action remains unclear.
In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of mitotic anticancer strategies.
Indicator lesions were measured before start of treatment and every two cycles, as a basis for the assessment of activity of the treatment.
Pathways with a FDR less than 0.01 were selected as significant and then hierarchically clustered on the basis of similarity of activity values.
When expressed on a cytosolic mass basis, the activities of all of the lipogenic enzymes in each tissue were depressed in R/O hens as compared with normal layers.
Group 1 has higher enzyme activities than Group 2. On the basis of enzymatic activities, all isolates of Group 1 and MWM 4/14 and RZWM 3/2 of Group 2 were selected for solid state fermentation.
b Calculated on the basis of volumetric activity and specific activity of each laccase variant.
