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Maybe the DNA damage can be explained on the basis of a systemic toxic effect.
Gene expression profiles represent a powerful tool to study the molecular basis of a systemic disease in living patients.
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Dhainaut et al. conclude that their results do not provide a strong basis for a systemic anti-inflammatory effect of rhAPC in vivo at the therapeutic dose used.
To assess the benefits of various interventions on the prevention of future diabetic foot ulcers, we searched for and reviewed all randomized clinical trials (RCTs) on the prevention of diabetic foot ulcers and evaluated their efficacy and scientific validity on the basis of an established systemic grading system.
These observations constitute the basis of a minimally invasive systemic therapeutic modality for retinal diseases, including retinitis pigmentosa and AMD, where, in early stage disease, the iBRB is intact and impervious to systemically administered drugs.
Generation of demolition waste data at the county level is the basis of the design of a systemic model for CDW management in a region.
We affirm that SLICC-12 has advantages with regard to diagnostic sensitivity in comparison with other classification grounds on the basis of our study of (1) patients in our regional register with confirmed and well-characterized SLE and (2) autoantibody-positive patients who had been referred to rheumatology specialists on the basis of a fair suspicion of systemic autoimmune disease.
Hence, the SLICC-12 criteria were applied to confirmed cases in our regional SLE register, as well as to individuals who were referred to rheumatology specialists on the basis of a fair suspicion of systemic autoimmune disease, including the presence of any SLE-related autoantibody.
These observations may provide evidence of a systemic immune basis for smoking-related lung parenchymal destruction.
Therefore, it is logical that there should be a stratification on the basis of systemic inflammatory response measurement within randomised clinical trials of cancer therapeutics (McMillan, 2013b).
On the basis of these results, systemic NAC administration seems to be a potent option to prevent poor healing outcomes under both age- and mechanically compromising conditions.
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