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In contrast, a combination of gemcitabine and erlotinib has been approved for use by the United States Food and Drug Administration (FDA and European Medicines Agencyy (EMEA) as a treatment for PDAC patients on the basis of a randomized trial, showing a overall gain in median survival of 2 weeks [ 159].
PCV7 was licensed on the basis of a randomized controlled trial in The Northern California Kaiser Permanente health care system, which demonstrated 97% efficacy against PCV7-serotype IPD when administered on a schedule of dosing at 2, 4, 6, and 12 15 months of age (9 ).
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A factorial model on the basis of a completely randomized design was used to analyze the data collected from 234 LUT.
A factorial model on the basis of a completely randomized design was used to analyse the data collected from 236 land units.
Treatments including MSW levels at (0 (control), 15 (MSW1), 30 (MSW2) and 60 (MSW3) t ha−1 dry weight) and usage time (yearly (T1) or biyearly usage (T2)) were tested in a factorial experiment on the basis of a completely randomized block design with three replications.
Although only 20% of patients present with localized disease amenable to potentially curative resection, on the basis of a few randomized trials [ 130– 132], the current accepted standard of care is adjuvant gemcitabine or 5-FU chemotherapy, while there have been no conclusions regarding the role or timing of adjuvant chemoradiation [ 133].
On the basis of all randomized patients, the rate of complete cytogenetic response (CCyR) at 12 months was similar between the bosutinib (70%) and imatinib (68%) treatment arms, although the rate of major molecular response (MMR) at 12 months was significantly higher with bosutinib (41% vs. 27%; P < 0.001) 19.
A suboptimal value of these parameters is computed on a per-cell basis by a randomized local greedy search algorithm.
Treprostinil was approved by the FDA in 2002 for continuous subcutaneous infusion on the basis of a 12-week, multicenter, randomized, double-blind, placebo-controlled trial.
On the basis of 14 randomized trials, we found a moderate quality of evidence supporting the beneficial effects of transabdominal guidance during embryo transfer compared with conventional clinical touch in clinical pregnancy and ongoing or live birth rates.
On the basis of 6 randomized controlled trials comparing artesunate and quinine, a recent Cochrane review recommended artesunate as the first-line treatment in adults with severe malaria in such areas (7 ).
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