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On the basis of a compound equipotently inhibiting HIV-1 and 2 proteases (PR), we have designed a pseudopeptide inhibitor, QF34, that efficiently inhibits a wide variety of PR variants.
The classification of compounds into these two kingdoms aligns with most modern views of chemistry and is easily performed on the basis of a compound's molecular formula.
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On the basis of an in-source compound decomposition, the HR fragmentation pathways were studied.
The libraries of metabolite spectra were obtained on the basis of a database of pure compound spectra acquired by use of a particular pulse sequence and acquisition conditions, namely, the NOESY-presaturation pulse sequence with 4 s acquisition time and 1 s recycle delay [ 26].
On the basis of model compounds, a significant decrease in rate upon sulfur substitution would suggest that chemistry is rate-limiting.
It was proposed on the basis of model compound studies that enzyme binding factors such as steric strain would sufficiently weaken the Co C bond so that homolysis would be a plausible step in B12 enzymatic reactions.
They are calculated on the basis of the available safety data of a compound.
On the basis of compound availability and the presence of a unique chemical scaffold, 30 of the 104 compounds were subsequently selected and retested in a dose-response assay (Table 1).
On the basis of crystallographic data, compound 1 contains a monomeric anion with distorted octahedral geometry.
On the basis of crystallographic data, compound 1 contains a Gd III) metal center that is coordinated to seven oxygen atoms of two tridentate and one monodentate H2pydc ligands and two coordinated water molecules.
Minor peaks do not represent pregnane-like compounds on the basis of a MS data comparison.
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CEO of Professional Science Editing for Scientists @ prosciediting.com