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Getting at the developmental genetic basis for variability is different from the developmental genetic basis of phenotypic variation in specific developmental contexts.
Differential selection in heterogeneous environments can result in adaptive radiation when there is a genetic basis for variability in organisms' success in exploiting alternative resources [ 1- 5].
Other modeling approaches to incorporate development rate variation stochastically by treating development rate as a random variable dependent on the variability in the level of catalytic enzymes [ 126- 128], positing a biophysical basis for variability.
The results presented here for the first time in mice may suggest a genetic basis for variability of the evaluated traits, thus opening the possibility to be implemented in selection schemes.
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The study of the developmental basis for phenotypic variability addresses a higher level of abstraction in that it deals with the tendency of developmental systems to change, amplify, or reduce the expression of genetic variation at the phenotypic level.
So what is the biological basis for differential variability?
The basis for marked variability in clinical presentation and disease severity is unknown.
Experiments that identify such a genetic basis for phenotypic variability are reviewed in Conover and Baumann (2009).
Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests that there is a genetic basis for this variability.
RhoB has different effects on cell migration depending on the cell type and conditions, but the molecular basis for this variability is unclear.
Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS.
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