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The mechanical properties of aortic elastin vary regionally, but the microstructural basis for this variation is unknown.
The genetic basis for this variation has remained elusive.
Neuropathologic and clinical diversity characterize C9ORF72 repeat expansion carriers, but the molecular basis for this variation remains elusive.
Longitudinal studies take advantage of variation among individuals, and it is relevant to consider the underlying basis for this variation.
However, the genetic basis for this variation would have to be examined in order to predict an evolutionary response.
One of the most intriguing aspects of ageing is how different the ageing process is from person to person; the basis for this variation is largely unknown.
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For nearly 3 decades scientists have been searching for the genetic basis of this variation.
Wild relatives of crops may contain allelic variation for genes determining the concentrations of these beneficial phytonutrients, and therefore understanding the genetic basis of this variation is important for breeding efforts to enhance nutritional quality.
The genetic basis for this heritable variation has been the subject of a comprehensive study by our lab, and progress has been made in understanding the variety of mechanisms, some species-dependent [8], that control expression of this integrin.
Identifying the genetic basis for this natural variation is paramount both for breeding programs and for elucidating which genes contributed to crop evolution during domestication and selection processes.
This difference in binding behavior is presumably the basis for the variation in susceptibility to dietary-induced hypercholesterolemia and atherosclerosis between mice expressing either apoE3 or mouse apoE.
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