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Understanding the basis for this preference might shed light on how DNA replication and DNA repair depend on the nuclear lamina network [7], [85], [86].
Our structural data reveals the basis for this preference - in E. coli SSADH a three-residue deletion (of the human sequence 261RKN263, Figure S2) in the loop connecting s5C and h6 permits accommodation of the extra phosphate group of NADP+ (2'phosphate: Figure 3B, 4A and B).
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Here we investigate the structural basis of this preference for small acyl groups using the crystal structure of the thermostable Thermotoga maritima CE7 acetyl esterase (TmAcE) complexed with a non-cognate substrate analog.
What is the molecular basis of this preference?
Higher durability of concrete compared to wood also provides an important basis for the preference of concrete as the construction material for railway track sleepers.
The basis for the preference to CRF in CRF2-R mice is not clear, but it may be a consequence of the rewarding effects of dopamine release caused by CRF activation of CRF1-R expressing neurons in the ventral tegmental area [5], [35].
The mechanistic basis for the preference of recruiting autoreactivity to neuronal antigens remains unclear.
Experiments were also designed to establish whether dsRBZFPs such as JAZ have differential binding activities for host dsRNAs compared to viral RNAs and to evaluate the structural basis for the preference of dsRBZFPs for binding to dsRNA over DNA and tRNA.
The molecular basis for these preferences is unknown.
The biophysical basis for this extraordinary substrate preference is presently an unresolved question.
The heterogeneous distribution of snails, if it is stable over time and patches are sufficiently large, might be the basis for habitat preference by jaw type.
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