Sentence examples for basis for this differential from inspiring English sources
The basis for this differential regulation of immediate-early genes and substance P vs opioid peptides is not clear, but may be related to the transmitter systems affected by methylphenidate.
The molecular basis for this differential regulation of growth by TNF is not understood.
The basis for this differential effect remains to be resolved but may be to due differences relating to their binding affinities to fodrin.
The basis for this differential response is not known but may be related to both tissues originating from different types of precursor cells, having different differentiation potential [26], [27].
These studies demonstrate a profound difference in stability of the B-pentamers in Stx1 and Stx2, illustrate the mechanistic basis for this differential stability, and provide novel reagents to test the basis for differential pathogenicity of these toxins.
Interestingly, while Nrf2-regulated antioxidant and detoxifying (phase I/II conjugating) enzymes were downregulated in RS cells, Nrf2-regulated molecular chaperones (including members of Hsp22, 40 and 90 families) were largely upregulated in the same cell type; the basis for this differential regulation of distinct subsets of Nrf2 target genes is currently unclear.
By comparing these structures to each other and to previously determined structures of AAG bound with high affinity to double-stranded DNA (dsDNA), we can investigate the molecular basis for the differential affinities of this DNA repair protein for DNA and explore the recognition events involved in identifying DNA lesions.
An interesting challenge of future research will be to analyze the basis for the differential response of these two tissues, in particular, whether this is due to differences between the interaction of (pre)adipocytes with their stromal environment or to adipocytes originating from distinct precursors with different capacity to respond to the high fat diet, or a combination of both.
In fact, molecular dynamics simulations have suggested that hB2AR is also able to adopt a helical ICL2 conformation and form the ionic lock in the inactive state and that this inactive conformational equilibrium in hB2AR may form the basis for the differential basal activity observed relative to tB1AR and hAA2AR [36].
