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We also note that other studies have provided related strategies for drug discovery, again using expression signatures as the basis for the screen.
A total of 271 microtitre plates of clones were used as the basis for the screen.
As in genetic screens, an important feature of chemical screening is consideration for the screening assay, that is, the phenotypic feature that is the basis for the screen.
The basis for the screen was the isolation of sem-3 inx-9 animals that did not bloat with eggs, indicating the presence of a linked sterile or lethal mutation (see Materials and Methods).
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Our data provide information regarding xylA diversity in nature, and can be a basis for the screening of novel xylA genotypes for practical applications.
Such pharmacophoric constraints can be implemented in GOLD [46] as well as in many other modern docking programs, and are the basis for the screening program FlexX-Pharm [47], where ligands are incrementally constructed into the active site in a manner incorporating "look-ahead checks" to ensure that desired interactions are formed.
"It does seem it ignores the whole basis for the screener ban, which was to reduce piracy and help preserve the industry for films large and small," Taylor said.
This is the first genome-wide expression profile of S. flexneri genes, pseudogenes, and noncoding regions, which can be used as a basis for the screening of overlooked genes.
The multistep model has also formed the basis for the screening programmes instituted for cervical and breast cancer.
The basis for this screen relies on the fact that ain-1, encoding the C. elegans miRISC component/GW Protein homolog, is non-essential (due to a redundancy with the C. elegans ain-2 gene), displays a variety of pleiotropic phenotypes that can serve as the starting point for an enhancer screen.
As the basis for this screen derives from sensitivity to an exogenous agent, the utility of the 6-OHDA screen for the elucidation of molecules regulating endogenous, DAT-1−dependent DA synaptic events is limited.
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