The mean value provided the basis for the phenotype comparison.
Second, when addressing the molecular basis for the phenotype of miR-100 and miR-99a, FKBP51 was identified as a novel target of both miRNAs.
The reduced expression of multiple wax-related genes uncovered through microarray analysis, beginning from saturated fatty acid biosynthsis to the two branches of the wax biosynthesis pathway, provided a biochemical basis for the phenotype of reduced cuticular wax content.
To determine the genetic basis for the phenotypes of pgr7, we determined the segregation ratio of wild type to mutant in F2 plants of wild type x pgr7.
For each of these knockdowns, the developmental defects were accompanied by significant decreases in global protein synthesis, suggesting a potential molecular basis for the phenotypes [ 15].
Although a successful model would not be able to explain the mechanistic contribution of the loci, it would inform that sufficient information on the genetic basis of the phenotype for sensitive prediction had been learned.
In order to understand the mechanistic basis for this phenotype, we compared the HER2-regulated transcriptome in MCF10A cells with the activated HER2 oncogene-regulated transcriptome in MCF10HER2 cells to identify changes in gene expression that could play a role in HER2 oncogene-driven increased insulin-independence.
To further refine the molecular basis for this phenotype, we assayed the effects of single amino acid substitutions in transgenic animals and determined that the arginine within the evolutionarily conserved E/N/DRY motif is critical for receptor function in mediating germ cell migration within an intact developing embryo.
HbSS erythrocytes are known to have reduced tolerance for oxidative stress, yet the basis for this phenotype remains unknown.
Future studies are justified to understand the basis for this phenotype, for example by investigating its genetic origins, as a means of defining new pathways involved in the pathogenesis of age-related bone loss.
The cellular basis for this phenotype is unclear, however, it might explain the presence of small clusters of Stra8-positive cells at the caudal pole of some mutant gonads.
