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Importantly, the mechanistic basis for the pathway downstream of Rho and Rho kinases resides in a previously unidentified process, the interaction of LIMK1/2 with fascin-1.
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Mechanistic studies have shown that the molecular basis for this pathway is the nicotinergic acetylcholine receptor (nAChR), which is also present in the sympathetic part of the autonomic nervous system [ 6, 12].
Sensitive patients can then be further classified on the basis of the pathway responsible for everolimus efficacy (for example, the PI3K-dependent 'classic' pathway or the LKB1/AMPK metabolic pathway).
MetaCyc and BioCyc provide the basis for developing pathway genome databases (PGDBs) and metabolic models for non-model organisms using the Pathway Tools software (Karp et al. 2010).
These predictions may set the basis for signaling pathways in the inner ear, subject to experimental validation.> In order to identify inner ear miRNAs, the genes associated with "impaired hearing" (MP 0006325) and "deafness" (MP 0001967) were downloaded from MGI (Additional file 3: Table S3).
The vagus nerve is the structural basis for the cholinergic anti-inflammatory pathway (Ref. 123), which inhibits the innate immune response via the release of acetylcholine.
The data provide a clear and solid basis for the use of HH pathway antagonists in the control of human CCs and their metastases.
This minireview summarises recent advances in this field and provides a theoretical basis for the enzymes in lipogenic pathway as a new class of molecular targets to induce cancer selective cell death.
This study was designed to elucidate the electrophysiological basis for dual pathway conduction and HEA.
The structure of Thermotoga maritime together with the one from A. aeolicus provided the basis for a proposed pathway of dsRNA recognition and cleavage by the bacterial RNase III members [ 7].
KEGG Orthology (KO) consisting of manually defined ortholog groups that correspond to KEGG pathway nodes and BRITE hierarchy nodes, is the basis for the representation of KEGG reference pathway maps and BRITE functional hierarchies (Kanehisa et al.[2010]).[2010]
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