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This approach to designing carbohydrate-based scaffolds should provide a basis for the functional development of glyco-decorated biointerfaces for cell culture applications.
Lin Y, Dötsch V, Wintner T, Peariso K, Myers LC, Penner-Hahn JE, Verdine GL, Wagner G. Structural basis for the functional switch of the E. coli Ada protein.
Structural and mutational analyses reveal the chemical basis for the functional properties of photoswitchable fluorescent proteins and provide the basis for subsequent coherent engineering of this subfamily of Dronpa homolog's.
Revealing the molecular basis for the functional divergence, we report here the crystal structure of MDA5 bound to dsRNA, which shows how, using the same domain architecture, MDA5 recognizes the internal duplex structure, whereas RIG-I recognizes the terminus of dsRNA.
In the last case study, we superimposed 12 BH3 domains from pro-apoptotic proteins, and found that there is a structural basis for the functional segregation of these proteins into activators and enablers.
The energy consumption of the brain does not vary greatly over time, but active regions of the cerebral cortex consume somewhat more energy than inactive regions; this forms the basis for the functional brain imaging methods PET, fMRI, and NIRS.
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Analysis of the bestrophins from a phylogenetic perspective may provide the basis for understanding the functional diversity within this conserved protein family.
However, structure-to-function mappings from the conventional functional MRI literature (Price, 2012) provide a strong basis for interpreting the functional roles of these sub-networks.
The identified biological processes and signalling pathways collectively targeted by co-expressed miRNAs in CRC provide a basis for understanding the functional role of miRNAs in cancer.
Using the new crystal structure, we examined the network of contacts among the protein subunits from a structural perspective, which provide the basis for elucidating the functional organization of the complex.
It is generally accepted that domains often act as functional units [7], [8] creating a basis for the complete functional repertoire for proteins.
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