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Fetal and uterus dimensions were precisely measured in 23 pregnant women, who formed the basis for the dose calculations.
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Results from this proof-of-concept study were therefore consistent with the cell culture studies and provided the basis for the doses selected in the phase II study.
These data indicate that the interaction between D-CblL and Drk underlies the functional difference between the D-CblS and D-CblL, and provide the basis for the dose-dependent, negative effects of D-CblL on EGFR signaling.
Meal B was consumed on two occasions (B1 and B2): once using carbohydrate counting as the basis for the insulin dose (about half the dose of insulin used in meal A) and once using the FII algorithm (the same dose as meal A, since both meals have the same insulin demand [FII = 60]).
Instead of this, the WHO DDD (average defined daily dose) is used as the basis for the equivalent dose by payers.
This study was designed to evaluate the efficacy and safety of 4 doses of GP MDI to serve as the basis for selecting the dose(s) that produce a consistent 12- and/or 24-hour duration of action for more definitive studies.
The results from these publications also served as a basis for the radiation dose report published by Weber et al. that contains dose calculations for various bone imaging agents [23].
The primary objective is determination of the in vivo MIC as the basis for rational dosing (the MIC is the concentration at which the parasite multiplication factor per asexual cycle is 1).
As examples of this approach, in this paper we use the extensive literature on chloroform to analyze the biological basis for the nonlinearity in dose-response for chloroform, a hepatotoxicant and nongenotoxic carcinogen in rodents.
Nontraditional end points such as measurements of drug effect or functional imaging have not been routinely incorporated into phase I trial design and have rarely formed the basis for future dose selection or trial design (Parulekar and Eisenhauer, 2004).
Although we do not know the basis for dose dependence, it is reproducible; the data shown depict the average of four independent experiments.
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