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These data indicate that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse, thus providing a potential mechanistic basis for the distinct pharmacological profiles of direct CB1 agonists and inhibitors of individual endocannabinoid degradative enzymes.
To investigate the biochemical basis for the distinct functions of Sox2 and Sox17, we solved the crystal structure of the high mobility group domain of Sox17 bound to a DNA element derived from the Lama1 enhancer using crystals diffracting to 2.7 Å resolution.
In chordotonal organs, NOMPC and IAV proteins show a striking segregation into distal and proximal ciliary zones respectively, revealing a structural basis for the distinct roles of the TRPN and TRPV channels in sensory transduction and amplification.
While these data establish some molecular and in certain cases, lineage and clonal relationship of neurons and hair cells, the molecular basis for the distinct differentiation of either cell type has not been investigated beyond the transcriptional regulation of Neurog1 and Atoh1 [20] or short range interactions mediated by delta-notch [23].
The biologic basis for the distinct actions of NOTCH1 in regulating lung cancer cell growth is not well understood.
Specific chromosomal aberrations are associated with distinct gene expression profiles which characterize spontaneously regressing or aggressive infant NB, providing the biological basis for the distinct clinical behaviour.
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The molecular basis for this distinct substrate specificity of PpAOC2 and the mechanism of the cyclization reaction catalyzed by PpAOC1 and 2 has recently been investigated by X-ray crystallography [ 22].
The basis for these distinct differences is not well understood.
More work is needed to resolve the basis for these distinct conclusions.
For 49 human bZIP TFs, bZIPDB ID was assigned on the basis of the distinct mRNA transcript.
The molecular basis for these distinct physiological roles is unknown.
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