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It serves as the basis for the binding of further kinetochore proteins during mitosis.
Jia, Z., DeLuca, C. I., Chao, H. & Davies, P. L. Structural basis for the binding of a globular antifreeze protein to ice.
Here, we provide the thermodynamic and structural basis for the binding of this motif by the Src SH2 domain.
To rationalize the structural basis for the binding of LILRA3 to HLAIs, we attempted to characterize the structure of LILRA3 in the HLA-binding region.
The molecular basis for the binding of tyrosine-based and dileucine-based motifs to AP complexes has been explained by X-ray crystal structures [11], [12].
In order to determine the structural basis for the binding of the substrate and molecular mechanism for the hydrolysis and transglycosylation activities, we solved the structures of Endo-A in complex with an oxazoline ion intermediate mimic – Man3GlcNAc-thiazoline [22] and an acceptor substrate – GlcNAc-Asn.
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We have successfully solved the cocrystal structure of 52 in complex with BRD4-BD1, providing a solid structural basis for the binding mode of compounds of this series.
Finally, the molecular basis for the binding affinity of the peptides for the Fc fragment of hIgG was elucidated by molecular dynamics simulations.
These structural differences may provide a basis for the differential binding of proteins that mediate dendritic transport of pre-miRs, or that prevent pre-miRs from being prematurely processed into mature miRNAs during the transport process.
Our in silico modeling suggests a structural basis for the RNA binding of Gadd45a.
On the basis of binding site identification, PHD3 utilizes two separate surfaces for the binding of H3K4me3 and CYP33 RRM.
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