As we did not find notable differences in program effects for demographic subgroups, we do not see any basis for targeting the programs to any of these subpopulations.
Taken together, our results expand the knowledge base available for evaluating, designing and developing new metal-based anticancer drugs that may provide the basis for target-specific therapeutics.
Moreover, the maximum standardized uptake value (SUVmax) as a common quantitative measure of the focal FDG uptake may be helpful for therapy response assessment [5] or as a basis for target volume definition in radiotherapy planning [6,7].
As such, they do not only provide a fallback option to the above-mentioned strategies, but rather the basis for target determination in line with the two-protocol approach.
The special section shows that advances in SWAT modeling provide a powerful basis for targeting conservation investments to protect water quality in the Great Lakes Basin, while also demonstrating opportunities to further refine the models.
Together, our work will not only facilitate the current understanding of mTOR biology and possible future research directions, but more importantly, provide a molecular basis for targeted therapies aiming at key oncogenic members along the mTOR signaling pathway.
In summary, our data provides the genetic and biochemical evidence to reveal the molecular mechanism by which DNA damage activates NF-κB through CBM complex, therefore, providing a molecular basis for targeting the CBM complex to block DNA damage-induced NF-κB pathway.
Resolving funding issues will require greater consideration by governments and industry groups of their social responsibilities to communities and the environment; particularly as this social learning model is posited for more broad-scale use in providing multi-level governance linkages and as a basis for targeting interventions to address policy gaps or failure.
Drawing on the experience of a recent research project examining the relationship between livestock farming systems and microbial watercourse pollution the paper reflects critically upon efforts to develop an interdisciplinary assessment of the factors that may affect the loss of potential pathogens from agricultural land to water courses as the basis for targeting high risk fields and farms.
