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Using the lentiviral reporter system, it will be possible to confirm some of the predicted miRNA-target interactions in hepatocytes, which could then form the basis for targeted experiments in which the expression of individual miRNAs is manipulated, for example by genetic or antisense loss-of-function techniques.
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Despite public remarks by Mr. Obama and his aides on the legal basis for targeted killing, the program remains officially classified.
That is the welcome gist of the White House announcement that it will let congressional committees see classified documents presenting the administration's legal basis for targeted killing.
These results provide compelling support for DOT1L inhibition as a basis for targeted therapeutics against MLL.
At the landscape level, risk mapping can provide the basis for targeted surveillance of the host community.
Understanding of mTOR signaling provided the biological basis for targeted chemotherapeutics development, including several rapamycin analogues for treating breast and other cancers.
Differences in expression in the absence of apparent upstream sequence variation may be used as basis for targeted analysis of differential methylation (shown with asterisks*) of homologous promoters.
The objective of this study was to identify and validate pathways deregulated in CNS HGNET-BCOR as a basis for targeted therapy approaches.
Identification of genes involved in tumor progression and development provides the molecular basis for targeted therapy.
Unbiased functional resolution of genome-wide transcriptional profiles may, to this end, provide a rational basis for targeted optimization of phenotypic output [33] [35].
They also provide an inadequate basis for targeted interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com