Sentence examples for basis for selectivity from inspiring English sources
Molecular modeling of the SH2 domains of Stat3 and Stat1 bound to compound revealed that compound interaction with the hydrophobic binding site was the basis for selectivity.
Sequence and structural analysis of the SH2 domains of Stat3 and Stat1 revealed that the ability of the compound to interact with the hydrophobic binding site was the basis for selectivity.
This provides a basis for selectivity which is desired against breast tumour cells.
24 In the present study we developed dopamine D1 receptor models to better understand the molecular basis for selectivity between full agonists and structurally similar inactive compounds.
The latter inhibits hOGT in vitro (Ki=8 μM) and in vivo, although the basis for selectivity over other GlcNAc transferases remains to be fully explained [ 9].
To further understand the structural basis for selectivity, we determined the crystal structure of CpOGA in complex with GlcNAcstatin D. These data show that GlcNAcstatin D binds deep into the active site of CpOGA, with the sugar moiety adopting a E conformation, and assuming the same conformation as observed for the GlcNAcstatin C complex [ 41].
To understand at the molecular level the basis for the selectivity of Cpds 3, 30, 188, 3-2 and 3-7 and the absence of selectivity in the case of Cpd 30-12, we compared the amino-acid sequences and the available structures of the Stat3 and Stat1 SH2 domains and also examined how each compound interacted with both.
Having now identified several ligands with very good selectivity for bFFA2 over hFFA2, we next set out to define the molecular basis for this selectivity.
This chapter focuses on understanding the molecular basis for the selectivity and sensitivity of the pheromone olfactory system in insects.
However, the precise mechanism of action and the molecular basis for membrane selectivity are still a matter of debate.
The molecular basis for this selectivity was a different dissociation rate of the drug to a particular enzymatic form along the reaction pathway.
