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However, the recent determination of their molecular structures by X-ray crystallography has revealed unexpected parallels in the architecture of the two pores, providing a basis for possible functional analogies.
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These were not analysed further for possible functional significance.
Guided by CHAIN analysis, we compared these structures with that of another C. parvum CDPK outside the subfamily, CpCDPK1 [EupathDB cgd3_920, PDB: 3DFA], to understand the sequence and structural basis for possible C. parvum CDPK functional divergence.
While a structural role as a half-cystine provides a stability basis for possible selective pressure, it is less clear why this residue is conserved as a free cysteine (although free buried thiols can limit protein functional half-life).
The dual role of Δ11 desaturase in both the biosynthetic pathways of male and female pheromone provides a possible functional basis for the maintenance of allelic diversity.
We have shown that susceptibility SNPs frequently fall beneath ESR1 ChIP peaks and thus suggest a possible functional basis for several GWAS susceptibility SNPs.
Thus, the concordant elevation in p53 expression may provide one possible functional basis for robust p53 responses selectively in the proliferating compartments upon stress.
The extent of supercomplex formation, and the allosteric effect that it induces, could be different with the 5A and 5B isoforms, providing a novel possible functional basis for the existence of the isoenzymes.
One way to identify the possible functional basis of the mtDNA enrichment of D4a in longevity is to look for autosomal polymorphisms that are also enriched in D4a over other haplogroups.
Our findings identified the possible functions of these SNP loci, and provide the basis for subsequent functional research.
We wanted to do a phylogenomic mapping of viral AlkB-like domains as a basis for analysing functional aspects of these domains, because this could have some relevance for understanding possible alternative roles of AlkB homologues e.g. in Eukaryotes.
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