Sentence examples for basis for pathologic protein from inspiring English sources

Moreover, a recent study suggests that mutations in PSEN1 genes may produce defective lysosomal proteolysis, which could itself represent a basis for pathologic protein accumulations in neuronal cell death leading to the identification of novel therapeutic targets [ 49].

Protein scores are derived from ions scores as a non-probabilistic basis for ranking protein hits.

Identification of homologous proteins provides a basis for protein annotation.

Although the molecular basis for the pathologic diversity of sporadic FUS inclusion body diseases is entirely unknown, the clinical and pathologic features of the cases presented here suggest that late-onset BIBD may represent a unique or extreme example of sporadic MND within the diverse spectrum of FUS proteinopathies.

Molecular basis for protein synthesis by the ribosome.

Chang, Y. et al. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Yang, X. et al. Structural basis for protein-protein interactions in the 14-3-3 14-3-3 14-3-3y.

Hence, inhibition of pathologic protein-protein interactions is a very attractive mechanism for drug development.

Our study supports the need for more sensitive and quantitative approaches when evaluating the relationship between putatively pathologic proteins and disease phenotypes.

The BBB is important in maintaining brain homeostasis, and its role in the clearance of pathologic proteins is complex.

The pathologic basis for these therapeutic options and the advantages and disadvantages of each will be discussed.