Sentence examples for basis for initiation from inspiring English sources

The genetic basis for initiation and development of lung carcinoma has a clinical impact through targeted therapeutics, diagnostic tools, prognostics, and predictive markers.

Studies have shown that the expression increases of TGFβ1 and TGFβ1 type I receptor (TβRI) is one pathological basis for initiation and development of immunologically-induced fibrosis in bovine serum albumin (BSA) [ 8].

Hence, age-associated joint or cartilage changes may serve as a basis for initiation of hip OA triggered by risk factors such as genetic susceptibility, shared influence from the family environment or the individual environment, i.e., occupational exposure to heavy lifting has recently been reported to be associated with early hip structural abnormalities in 3.0 T magnetic resonance imaging [ 48].

Nevertheless, the immunostimulatory molecule(s) of A. fumigatus that are recognized by PRRs and the molecular basis for inflammation initiation are still under investigation.

12 These findings provided the basis for the initiation of the phase III READY trial, a randomized, double-blind, placebo-controlled study comparing the efficacy and safety of dasatinib and docetaxel/prednisone combination versus the current standard of care of docetaxel/prednisone plus placebo in men with mCRPC (Clinicaltrials.gov NCT00744497).

Previous work by our group [ 26], the study of Foest et al.[ 1], and the results of the current study, were the basis for the initiation of a Phase II trial which evaluates treatment with AEZS -125 in patients with advanced or metastatic LHRH receptor positive TNBC, and began patientrecruitment in January 2013.

The favorable safety profile of idelalisib allowed the administration of this oral PI3K-Δ inhibitor at the full single dosage with concomitant chemoimmunotherapy and provided the basis for the initiation of studies evaluating its efficacy in combination with rituximab or bendamustine ± rituximab, with fludarabine or chlorambucil.

The genes in this network are collectively informative as a molecular signature of this developmental window, similar to the concept of using disease-perturbed networks as a basis for understanding disease initiation and progression [ 35].

To provide a basis for understanding mechanisms for initiation of the cellular reaction, the junction of an incoherent grain boundary with microfaceted interfaces at both the rationally and the irrationally oriented interfaces of grain boundary allotriomorphs is examined with the Cahn Hoffman formalism.

The basis for choosing year 2002 for initiation of the study was twofold.

Monitoring EBV DNAemia is the basis for weighing decisions regarding initiation of pre-emptive or anti-EBV-related tumor therapy.