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The altered monoaminergic modulation at the mossy fiber synapse could be a candidate pathophysiological basis for impairment of hippocampus-dependent brain functions in schizophrenia.
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Furthermore, this study suggested that deficit schizophrenia is associated with frontal and parietal lobe impairment, and that temporal lobe dysfunction may be a common basis for cognitive impairment in schizophrenia as a whole.
The neuroanatomic basis for cognitive impairment in chronic kidney disease (CKD) is incompletely characterized.
The p53 pathway is activated by ribosome dysfunction, but the molecular basis for selective impairment of the erythroid lineage in disorders of ribosome function has not been determined.
We first investigated the molecular basis for the impairment of spatial memory seen following prolonged mGluR5 antagonism.
In vitro Ca++ imaging studies with organotypic hippocampal slices, primary hippocampal neurons and N2a cells expressing pro-aggregant TauRDΔ demonstrated dysregulation of neuronal calcium influx as a possible basis for plasticity impairment.
Musculoskeletal tissue experiences progressive damage, which is the basis for a functional impairment and a high disease burden.
Stress-induced structural remodeling in the adult hippocampus may provide a cellular basis for understanding the impairment of neural plasticity in depressive illness.
This is the first report of a possible genetic basis for acute renal impairment.
In health and health-related domains, this basis for classification is impairment in body structure and function [1,2].
Collectively, these findings represent a neuropathological basis for persistent cognitive impairment, hippocampal atrophy, and electroencephalographic changes observed in sepsis survivors [25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com