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Here, we reveal the structural basis for how these inhibitors retain activity against a disease-relevant, drug-resistant kinase mutant, while maintaining Src specificity.
However, the mechanistic basis for how these WhiB homologues sense and respond to endogenous and exogenous signals to exert their effect is not known.
To better understand the structural basis for how these small molecules target HSP70 and DnaK, we sought to generate crystals of protein inhibitor complexes suitable for analysis by X-ray crystallography.
To understand the molecular basis for how these mutations render the kinase refractory to inhibition, we also solved the crystal structure of FGFR4K harboring the V550L gate-keeper mutation.
Dietary agents can interfere with several cell-signaling pathways and the molecular targets modulated may be the basis for how these compounds not only prevent but also treat the diseases [ 5].
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The superimposition of the p120GAP/Ras and PlexinC1/Rap structures suggests the basis for how this residue determines the substrate specificity of these GAPs.
The spokesman said the responses, which are expected by Oct. 17, would form the basis for how the government proceeds.
The "Android Project Software Functional Requirements" document detailed Android's supported hardware features and the basis for how the new mobile software would operate in 2006.
The paper clearly lays out the basis for how the sites were selected and the companies were given no input or control over that process.
Custom tags permit JavaServer Pages (JSP) developers to simplify complex tasks, and they form the basis for how the JSTL is actually implemented.
That's the basis for how the process of commissioning art via The Commissioned goes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com