Climatological analyses are required to convert information gathered at a dispersed network of weather stations into more relevant forms (radiation, dew point, vapor pressure deficit) and to provide the basis for extrapolation of climatic variation across landscapes.
Provide information about the mode of action (MOA) of chemicals, i.e. the mechanism of toxicity; in turn, reducing the uncertainties involved in chemical risk assessment by providing, for example, a basis for extrapolation of the effects across species.
The generated data indicate comparable kinetic properties of pig and minipig AChE and may provide a kinetic basis for extrapolation of data from pig studies to humans.
The greater the similarities of the entities, activities, and organization of the mechanisms in both populations, the stronger is the basis for extrapolation; the greater the differences, the weaker the basis (but see Howick et al. 2013; see also the sections on extrapolation in the entries on molecular biology and experiment in biology).
If we already knew how the causal mechanism worked in the target, we wouldn't need the model to serve as the basis for extrapolation (for similar criticisms see Lafollette and Shanks 1996).
Such a parameterization offers the basis for extrapolation and prediction between different drugs in the same disease or within and between drug classes.
A validated laboratory marker of clinical protection would provide a robust basis for extrapolation of clinical efficacy data derived in specific settings to other regions or populations.
Such information, used in conjunction with that obtained from other preclinical studies, can then form a reasonably sound basis for extrapolation to man.
