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This information provides a basis for enzyme engineering to manipulate substrate specificity and to design effective biocatalysts with glycosylation and/or deglycosylation activity.
12a, 24 Modeled substrate complexes of HNLs were also successfully used as the basis for enzyme engineering.
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He founded and headed the Department of Biophysics, and in doing so, laid the foundation for enzyme engineering today a critical component of the food and pharmaceutical industries.
Understanding the fundamental basis of long-range communication represents a major challenge in structural biology, which is significantly important for enzyme engineering and rational protein design.
The thermostability of proteins is particularly relevant for enzyme engineering.
Cloning of chitinase genes has been carried out for studying aspects of chitinase sequence variations, functional characteristics, changes in enzyme induction pattern, and for enzyme engineering.
Importantly, the EM gives rise to a number of new insights into the molecular basis of the temperature control of enzymes and their environmental adaptation and evolution, it is consistent with active site properties, and it has fundamental implications for enzyme engineering and other areas of biotechnology.
It will be useful to study the catalytic mechanism of β-elimination enzymes and will provide a basis for further enzyme engineering.
This knowledge will provide the basis for rational enzyme engineering and/or modification of reaction conditions.
Although an enzyme variant where all the eight N-glycosylation sites were mutated hardly showed catalytic activity and thus does not describe a meaningful tool for medical applications, the here described glyco-library of HRP C1A describes a very useful basis for further enzyme engineering approaches.
The significant functions of these compounds make their regulators critical targets in genetic engineering applications for improving plant qualities, and for enzymes engineering TF is one kind of candidates [ 20].
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