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The current study was performed as part of a long-term research program on the genetic basis for complex phenotypes in the Hutterites (63– 63).
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They are particularly useful for complex tissues, like brain, where changes in chromatin state, or abundances of a subset of cells, are important for complex phenotypes.
Agniel's research was focused on statistical methods for complex phenotypes where diverse measurements are required to accurately capture the multidimensionality of disorders.
These population attributes enhance the power of genetic association studies for complex phenotypes.
To address the challenge of understanding the genetic, molecular, and cellular basis of complex phenotypes, we have, for the first time, developed a structural systems biology approach for genome-wide multiscale modeling of nsSNPs - from the atomic details of molecular interactions to the emergent properties of biological networks.
These lines have been used for three decades to map the genetic basis of complex phenotypes, and allow detection of causative genetic loci even for traits with modest heritability (Belknap 1998).
The increasing availability of high-throughput genetic markers has prompted the development of new methodologies for identifying and targeting the molecular basis of complex phenotypes in breeding programs.
Understanding the genetic basis of complex phenotypes, i.e. genetic architecture, is of fundamental importance both for modeling evolutionary change and for genetic manipulation of crop plants.
Progress in the field of strain engineering is being made by identifying the genetic basis of complex phenotypes, engineering new phenotypes, and combining beneficial phenotypes in industrial hosts.
The lack of knowledge on the genetic basis of complex phenotypes restricts our ability to rationally engineer them.
Understanding the genetic basis of complex phenotypes in rice is a major challenge.
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