Sentence examples for basis for complex diseases from inspiring English sources
It has been proposed that accumulation of multiple mildly deleterious rare, but not monogenic, gene variants in individual human genomes has a huge impact on the genetic basis for complex diseases contributing with a large relative risk at the individual level [ 78].
One aim of using animal models for complex diseases is to detect the genetic basis of these diseases.
Before the era of high-throughput analysis, typical translational research initiatives, aimed at defining the molecular targets for complex diseases, were performed on gene-by-gene basis.
4. Medical biostatistics for complex diseases.
Cardon, L.R. & Bell, J.I. Association study designs for complex diseases.
This situation is common for complex diseases.
It offers readers the background they need to understand the latest findings in genetics and those still to come in the search for the genetic basis of complex diseases and traits.
Nonetheless, genome-wide association studies (GWAS), the main approach for investigating genetic basis of complex diseases, have been generally unsuccessful in identifying SNPs showing genome-wide significant (P ≤ 5 × 10−8) association with DR (Dudbridge and Gusnanto 2008).
Integrating gene co-expression networks with allelic association studies holds great promise for elucidating the genetic basis of complex diseases.
