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Several agent classes have a strong basis for combination with ADT, including antiproliferatives, antioxidant micronutrients (selenium), antiestrogens, and nonsteroidal anti-inflammatory drugs (selective cyclooxygenase-2 inhibitors).
The ability of exogenous IL-12 to shift this balance strongly towards Th1 provides the immunological basis for combination with BCG for successful bladder cancer therapy.
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Although various types of anticancer drugs are able to arrest cells at specific cell cycle checkpoints, the ability of antimicrotubule agents to block cell cycle progression in G2-M phase is the biological basis for combination of these agents with radiation (Pawlik and Keyomarsi, 2004).
When preclinical findings suggest the basis for combination use, it is important to perform clinical studies with suggested the combination.
A significant reduction in glutathione synthetase and glutathione reductase transcripts by indisulam provided a molecular basis for its combination with platinum agents.
Its low toxicity profile makes dG a good basis for combination chemotherapy.
On the basis of these findings, they concluded that sorafenib does not seem to be a good candidate for combination with immunotherapeutic approaches, whereas sunitinib does.
Overall, a generic basis in combination with a flexible programming language facilitates a modelling process for complex and changing systems.
Overall, the underlying generic basis in combination with a flexible programming language facilitates the modelling process for complex and changing systems.
Our findings provide a molecular basis for the combination effect seen with dietary components, and indicate that ATRA may be a beneficial food component for cancer prevention when combined with EGCG.
If used, it should be on a limited basis and in combination with nondrug treatments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com