Sentence examples for basis for checkpoint from inspiring English sources

A similar threshold basis for checkpoint activation has been documented for other cell cycle checkpoints, notably the DNA replication checkpoint in which activation requires a certain quantity of single-stranded DNA (Branzei and Foiani, 2005).

Analyses of relative protein modifications and activations especially for checkpoint proteins will help us understand the basis of the change of S phase caused by nsp11.

By showing that Aurora B might contribute to checkpoint signalling independently of error correction, we provide the basis for a better molecular understanding of the checkpoint sensory apparatus.

Our finding that the very C-terminal Mad1 head is required for checkpoint activity without being required for any of the known Mad1 functions provides a basis to elucidate the molecular mechanism.

Furthermore, it will be of great interest to elucidate both the pathway mediating degradation of the 3′ strand and the mechanistic basis for the stimulation of DSB processing and checkpoint activation by DNA replication.

Further analyses of p53 downstream effectors (e.g., the cyclin/cyclin-dependent kinase inhibitor p21Waf1) may provide a basis for the unexpected absence of a G1 checkpoint in irradiated SVZ NSPs.

10/20/02 - The files for Checkpoint 2 have been updated.

Furthermore, the observation that ATIP3 promotes prolonged mitosis by extending the time of metaphase potentially reflects modulation of spindle checkpoint signalling and provides a molecular basis for elucidating the intracellular functions of ATIP3 in cell division.

The inherent decatenation checkpoint deficiency in normal stem and progenitor cells may constitute the basis for transformation and the earliest stages of carcinogenesis.

This is important as the genetic basis for amplification remains obscure, although presumably certain deficits in DNA repair, replication, or cell cycle checkpoints are required to permit amplifications to occur.

We suggest that the basis for this aneuploid accumulation is compromised topo IIα activity in cells that escape the G2 decatenation checkpoint.