For diagnostic accuracy studies in particular, complete reporting of all results on all levels (at the segment, vessel, and patient levels), if applicable, is the basis for fully characterising a test's diagnostic potential.
The importance of metabolic flux analysis as the basis of characterising cellular functions is discussed, with a description of the investigative tools and strategies that can be used for its assessment.
A successful strategy for characterising the basis of the cyclohexanone response would therefore likely be more broadly applicable.
Several possibilities for characterising a problem domain exist.
In our settings, non mitochondrial Bcl-2 can hardly account for an ER localisation (Fig. 5B); further experiments are required to identify the host compartment and characterise the molecular basis for such pro-autophagic functions.
To characterise the molecular basis for the differential responses of the cell lines to TGFβ, we analysed some of the Smad independent kinase pathways known to activate genes associated with ECM.[22] Overall, the levels of phosphorylated JNK did not vary following TGFβ treatment (Figure 5).
For example, we have recently characterised a multigenic basis for DNA replication and chromatin formation impairments in WHS (Kerzendorfer et al., 2013; Kerzendorfer et al., 2012).
The Abbasi family went to court and the Jerusalem district judge found "no factual or legal basis" for the takeover; indeed, he found it characterised by "an extreme lack of good faith".
A combination of genetic susceptibility and abnormal placentation is thought to constitute the basis for pre-eclampsia, and clinically, the syndrome is characterised by hypertension and proteinuria.
In particular, characterising these autoantigenic structures is an essential basis for understanding the pathogenesis of warm AIHA, whether associated with M. suis infections or in general.
