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Our findings suggest that unstructured everyday interactions, presented in a prose fashion, might not be a sufficient basis for acquiring gender-like subclasses, whereas structured input, presented in a rhyming and sung fashion is such a basis.
This data set can be expanded as further genomes become available and thus represents a valuable basis for acquiring divergence time estimates.
In Mozambique it is also the basis for acquiring a national identity card, which in turn is required for establishing a bank account and for accessing the social security system, among other things.
All these factors were taken into account in construction of the vignettes in the following way: medical education and exams typically consist of case vignettes, which after many hours of training become internalized and represent the basis for acquiring expertise and actual practice of medicine.
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To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA).
Indirect evidence for this pattern was also found in comparisons of age-prevalence curves between dry and rainy seasons, and in a malaria transmission model that explores the biological basis for acquired immunity and differentiates 'anti-disease' and 'anti-infection' protection [57].
The molecular basis for acquired resistance to Herceptin® is poorly understood, but may involve HER2-independent upregulation of phosphoinositide 3 (PI3) and mitogen activated protein (MAP) kinase pathways, possibly through upregulation of insulin-like growth factor-1 receptor (IGF-IR) or EGFR ligand activation [7].
While important and demonstrating that downstream aberration of the RB pathway can bypass the response to endocrine therapy, loss of RB or cyclin D1 amplification does not represent the principle basis for acquired resistance in preclinical models.
In a targeted approach aimed at understanding the genetic basis for acquired hormonal therapy resistance in ER-positive breast cancers, Toy and coworkers surveyed mutations and copy number alterations in 230 commonly mutated genes of tumors from metastatic ER-positive breast cancer patients [ 28].
While numerous unknowns remain regarding the role of ESR1 mutations in advanced, endocrine therapy-resistant breast cancer, their identification certainly opens exciting new avenues of research that will deepen our knowledge and understanding of the molecular basis for acquired endocrine therapy resistance.
The distribution of cell cycle phases with different DNA contents was analyzed using HCS on the basis of acquiring 10,000 events for each sample.
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