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This basic study was therefore important to study VSMC characteristics in normal canine great vessels and to set appropriate benchmarks for subsequent studies on tissue-engineering vasculature in animal models.
On the discovery of 1 as a potent STS inhibitor, a basic study was carried out to provide a preliminary structure activity relationship (SAR).[ 17] The main focus of that work was on ring contraction (from 7- down to 6- and 5-membered rings: compounds 2 and 3, Figure 1) and expansion (from 7- to 8-membered rings: 4, Figure 1) of the aliphatic ring of 1.
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So, the basic study is you've got two screens.
Further basic study is essential to sort out possible molecular relationships and to permit elucidation of the most critical regulatory circuits.
While these basic studies are designed to investigate physiology and pharmacology, TMS can be suitable as biomarker in individual patients.
Fourth, basic studies are needed to identify the enzymes other than ALDH2 involved in GTN metabolism.
Forty-five case reports/series and 9 basic studies were reviewed in detail.
Further basic studies are needed to elucidate the source of LysoPS.
Further clinical and basic studies are necessary to confirm the findings and to elucidate the underlying mechanisms.
However, these predictions do not provide definitive targets and additional basic studies are needed to provide clearer mechanistic information.
However, further basic studies are necessary to thoroughly clarify the therapeutic mechanisms of this treatment for acute MI.
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