Collectively, despite some current concerns for using engineered Cas9 and TALE for exploring uncharted cellular events, esp. in a physiologically relevant context, these tools undoubtedly open a new avenue to uncover novel events underlying gene expression regulation and dynamic nuclear organization of chromatin, and may greatly facilitate translation of basic studies into clinical therapies.
Currently, the research on miRNA-regulated PPI networks can be divided into two main areas: a) basic studies on the correlation between miRNAs and general PPI networks.
In this way, the study of far-field tephra occurrences also feeds back into the basic study of the eruption frequency/magnitude behaviours of volcanic systems, which in turn has important implications for risk assessments in relation to future eruption events [16, 17].
Basic, clinical and translational studies into the biology of cancer and the factors that contribute to its onset and growth.
Understanding the differences between breast cancers diagnosed during pregnancy and postpartum would better permit the translation of informative data from basic science and epidemiologic studies into the clinical care of young women's breast cancer.
These structure-function studies of GPCR signaling in native contexts will inform future studies into the basic biology of this large and clinically important family of receptors.
This list of genes that were down- and up-regulated during the activation of the zygote genome is a valuable tool which could be used in future studies into the basic molecular mechanisms determining the normal development of the pre-implantation embryo.
We divide current miRNA-regulated PPI networks into: 1) basic studies of miRNA-regulated PPI networks; and 2) identification of miRNA-regulated networks in diseases which covers most parts of current miRNA-regulated PPI network studies.
For each article meeting the inclusion criteria, basic study parameters were abstracted into evidence tables summarising the following: study design, primary focus, inclusion/exclusion criteria, interventions and how administered, subjects, outcomes, results, and quality assessment.
These factors should be incorporated into basic study design so that more advanced and informative analyses may be conducted.
