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We also determined the basic structural organization of the orthologous DUXY loci in human and common chimpanzee.
Frizzled receptors share the basic structural organization of G protein-coupled receptors (GPCRs) with seven transmembrane-spanning domains, and exhibit a complex N-glycosylated exofacial N-terminal region.
To better understand the evolution of the DUXY locus in primates, we investigated the basic structural organization of the orthologous locus on the chimpanzee Y chromosome.
These results suggest a basic structural organization of large-scale communication within brain networks that coordinate context processing, and provide insight into how apparently seamless cognition is constructed from these network communication modules.
The peptide P-NT.II retained at least the basic structural organization of the synovial membrane seen in the control wild-type mice (Fig. 7a), while the synoviocytes from mice treated with scrambled P-NT.II (Fig. 7c) were structurally indistinguishable from those seen in untreated joints (cf. Fig. 6).
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Taken together, the amino acid alignment survey, phylogenetic reconstruction, and recombination detection analyses do not only show the presence of the basic structural organization consisting of four DUXY gene copies in an ancestor of human and chimpanzees, but they also strengthen the DUXY1 gene to be rated as the prototype of the Y-chromosomal DUX genes.
Throughout this analysis, it was apparent that the basic structural organization as well as the overall content of the anatomy ontologies were more similar than different.
Detailed comparative analysis of the human and common chimpanzee DUXY locus allowed us to infer the evolutionary processes shaping its basic structural organization.
RNase II and RNase R share the same basic structural organization: a central catalytic RNB domain, two N-terminal cold shock domains and one C- terminal S1 domain.
Furthermore, the basic molecular and structural organization of synapses appears to be normal in the dP32 mutant, suggesting a direct role for this protein in synaptic function.
Herein, we discuss the principles of the structural organization of recently studied molecular systems, basic approaches for their assembly, and challenging directions for their practical applications.
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