Sentence examples for basic side chain from inspiring English sources

The tyrosine template was thus equipped with (i) a basic side chain of various flexibility, (ii) an acidic side chain, which incorporated the XPS fluorine tag, and (iii) a spacer-arm terminated by a primary amine for surface grafting.

All these results together with the structure activity relationships (SARs) indicated that these 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one 3-aryl-4-anilino-2H-chromen-2-one

It is concluded that not only the C-terminal residue, that we previously demonstrated, but also the N-terminal with its basic side chain, are important for achieving effective pain relief.

The WbmF active site contains conserved 3,5-epimerase features, namely, a positionally conserved cysteine (Cys133) and basic side chain (His90 or Asn213), but lacks the serine/threonine component of the SDR triad and therefore may not act as an oxidoreductase.

Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound.

Then, 1 mL of Sirius red dye, an anionic dye that reacted specifically with basic side chain groups of collagens under assay conditions, was added to 20 μL collagen solution of mouse skin or 400 μL of cell supernatant, and incubated with gentle rotation for 30 min at room temperature.

Compounds with basic side chains such as diaminopropionic acid were found to be good inhibitors (Ki: 7.2 μM).

This means that the acidic carboxyl ( ―COO−) groups of aspartic and glutamic acid are about equal in number to the amino acids with basic side chains.

Among the tested compounds those bearing two basic side chains at 2- and 5-positions exhibited a strong dose-dependent antiproliferative activity.

Moreover, it was highlighted that basic side chains, such as thiazolidines and imidazolidines, and free amino group, are relevant for design of promising antitumor and DNA binding compounds.

The structure-activity relationship study demonstrated the importance of the naphthalene moiety (as the B-ring), the basic side chains in the A-ring, and the methoxy group linked to the C-ring.