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The first level, or T1, entails the movement of results from basic science into the first human clinical trial.
"We're not going to just come up with one drug, we're going to build a company that's able to go from basic science into the clinic over and over again".
These complementary approaches led to the identification of several new disease-causative ciliary genes and also propelled the ciliary biology field from basic science into the biomedical realm.
Identification and functional investigation of causative genes have always been emphasized and the recent accessibility of high-throughput NGS has propelled the ciliary biology field from basic science into the biomedical realm.
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They stem partly from the timing of Flexner's (1910) report that recommended bringing basic sciences into the medical curriculum.
Our goal is a continuous feedback loop to accelerate the translation of data into knowledge from the basic sciences into the development of new treatments, translating the findings from clinical trials into everyday practice.
In 2003, NIH developed the "Roadmap for Medical Research," a collection of initiatives designed to find ways of motivating the translation of basic science into practice with the goal of transforming health care and outcomes.
Overall, Phase 2 aims to translate the promising indications from basic science into clinical practice demonstrating the effect of dietary sodium on blood pressure, risk factors for CKD progression and cardiovascular disease.
Instead, she "pushed our understanding all the way from the basic science" into clinical applications.
In a report accompanying the bill, the committee lauds the creation of NCATS, which it calls "nothing less than fundamentally changing the way NIH pursues the translation of basic science into treatments and cures".
It will seek to steer money to two main areas of research: translating basic science into new therapies, and developing innovative, out-of-the-box treatments that might not otherwise be financed.
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